PharmaMastery on Instagram: "Drug of the day: Rosuvastatin 💊 One of the most powerful statins, targeting HMG-CoA reductase, the key enzyme in cholesterol synthesis. But here’s the exam pearl: the biggest LDL reduction happens because the liver increases LDL receptor expression, pulling more LDL out of circulation. So it works by blocking production AND increasing removal. Used in hypercholesterolemia and prevention of heart attacks and strokes. Brand name: Crestor. Major adverse effects: myalgi