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Monoclonal gammopathy of undetermined significance (MGUS) is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. NEJM Editorial Fellow Katerina Lin, MD, shares some key points from a review published in October. | The New England Journal of Medicine
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Assuming there is no CRAB (hypercalcemia, renal insufficiency, anemia, bone lesions), what separates myeloma from MGUS (monoclonal gammopathy of undetermined significance)? >10% clonal plasma cells in the marrow, 3.0 g/dL M-protein in serum (paraprotein), Either A or B, Neither A nor B.
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